in situ tracking of defect healing and purification of

An in situ microenvironmental nano

An in situ microenvironmental nano-regulator to inhibit the proliferation and metastasis of 4T1 tumor Huijuan Zhang 1,2,3, Xiaoge Zhang 1, Yanping Ren 1, Fang Cao 1, Lin Hou 1,2,3, Zhenzhong Zhang 1,2,3 1. School of Pharmaceutical Sciences, Zhengzhou 2.

The Treatment Efficacy of Bone Tissue Engineering Strategy

2015/7/31However, there are very little data available regarding the postfracture bony defect healing efficacy under osteoporotic conditions. This study aims to investigate whether critical-sized segmental bone defects in a rabbit model of osteoporosis could be repaired using an allogenic stem cell-based tissue engineering (TE) approach and to investigate the potential influence of osteoporosis on the

Injectable Hydrogels for Cell Delivery and Tissue

Cell Delivery and Tissue Regeneration with in situ Forming Hydrogels Injectable hydrogels have been used to deliver a variety of cargo molecules, including growth factors, chemokines, and therapeutic cells to promote tissue regeneration in vitro and in vivo.These in situ forming materials are being used for the regeneration of a variety of tissues, including bone, cartilage, intervertebral

An in situ microenvironmental nano

An in situ microenvironmental nano-regulator to inhibit the proliferation and metastasis of 4T1 tumor Huijuan Zhang 1,2,3, Xiaoge Zhang 1, Yanping Ren 1, Fang Cao 1, Lin Hou 1,2,3, Zhenzhong Zhang 1,2,3 1. School of Pharmaceutical Sciences, Zhengzhou 2.

An in situ microenvironmental nano

An in situ microenvironmental nano-regulator to inhibit the proliferation and metastasis of 4T1 tumor Huijuan Zhang 1,2,3, Xiaoge Zhang 1, Yanping Ren 1, Fang Cao 1, Lin Hou 1,2,3, Zhenzhong Zhang 1,2,3 1. School of Pharmaceutical Sciences, Zhengzhou 2.

The Masquelet technique for membrane induction and the

The healing of critical sized segmental defects is an ongoing clinical problem. No method has achieved pre-eminence. The Masquelet technique is a relatively new innovation involving the induction of a fibrous tissue membrane around the bone defect site taking advantage of the body's foreign body reaction to the presence of a polymethylmethacrylate (PMMA) spacer.

Structural Changes in Double

Centimeters-long double-walled carbon nanotube strands were irradiated by a 355 nm pulsed laser. Multiwalled carbon nanofibers, hollow and solid onion-like nanoparticles, were found to be changed from DWNTs, induced by UV laser irradiation. As-grown Fe catalysts were also found to aggregate and were conveniently able to be removed by a dilute HCl solution. The structural changes in the DWNTs

Proteomics and Metabolomics for In Situ Monitoring of

Wound healing of soft tissue and bone defects is a complex process in which cellular differentiation and adaption are regulated by internal and external factors, among them are many different proteins. In contrast to insights into the significance of various single proteins based on model systems, the knowledge about the processes at the actual site of wound healing is still limited. This is

In situ prevascularization designed by laser

2019/7/3In vivo tracking of printed patterns could allow better control of bioprinting process, follow-up of the implanted cells migration, and evaluation of healing processes, even in deeper tissues. In one of our previous reports, we have demonstrated that MRI combined with MPIO cell labeling enabled cell pattern detection after in situ bioprinting onto mouse calvarial defect [ 94 ].

In situ tracking of defect healing and purification of single

and healing via increased defect mobility. In both cases, des-orbed impurities can be removed effectively by a gas ow or further liquid-state treatments. Some methods can more effectively than others eliminate impurities and/or defects and combinations of

LASIK

LASIK or Lasik (laser-assisted in situ keratomileusis), commonly referred to as laser eye surgery or laser vision correction, is a type of refractive surgery for the correction of myopia, hyperopia, and astigmatism. LASIK surgery is performed by an ophthalmologist who uses a laser or microkeratome to reshape the eye's cornea in order to improve visual acuity.

Research Paper Injectable and in situ crosslinkable gelatin

craniofacial defect mouse. Methods: Injectable and in situ crosslinkable gelatin microribbon (μRB)-based macroporous hydrogels were developed by wet-spinning. Injectability was optimized by varying concentration of glutaraldehyde for intracrosslinking of μRB

Noninvasive in vivo 3D bioprinting

Noninvasive installation of the conformal cell-laden scaffolds into the defect could avoid the implantation process–caused iatrogenic injury. Here, a conformal ASC-laden scaffold was noninvasively printed in situ for promoting the healing of the muscle defect in vivo.

Multiscale Nature of Stress Corrosion Cracking

Multiscale simulations of stress corrosion effects and surface response to charging J.-M. Albina1,2,3 Y. Umeno3, G. Moras1, C. Elssser1,2, P. Gumbsch1,2 1 Fraunhofer Institute for Mechanics of Materials IWM, Wohlerstr. 11, 79108 Freiburg, Germany 2 Karlsruhe Institute of Technology KIT, Institute for Applied Materials, Kaiserstr. 12,

Potential sealing and repair of human FM defects after trauma

cal solutions to improve healing of the FM after trauma or rupture. Several novel sealing techniques are aiming to restore a physical barrier against infection encouraging re-accumulation of AF. The approaches either (a) seal the FM defect with natural, synthetic or

The Masquelet technique for membrane induction and the

The healing of critical sized segmental defects is an ongoing clinical problem. No method has achieved pre-eminence. The Masquelet technique is a relatively new innovation involving the induction of a fibrous tissue membrane around the bone defect site taking advantage of the body's foreign body reaction to the presence of a polymethylmethacrylate (PMMA) spacer.

Embryonic stem cell therapy improves bone quality in a

In the current study, we used an estrogen-deficient mouse model of osteoporosis to test the efficacy of a cell-generated bone tissue construct for bone augmentation of an impaired healing fracture. A reduction in new bone formation at the defect site was observed in

creos™ xenoprotect

Good clinical results 1-5 In a multicenter randomized controlled clinical trial, implant survival and success rates are high. 4 The use of creos xenoprotect versus a competititor membrane for simultaneous implant placement and guided bone regeneration (GBR) at dehisced implant sites similarly reduced defect height and improved secondary measures, indicating non‐inferiority. 2,4

Multiscale Nature of Stress Corrosion Cracking

Multiscale simulations of stress corrosion effects and surface response to charging J.-M. Albina1,2,3 Y. Umeno3, G. Moras1, C. Elssser1,2, P. Gumbsch1,2 1 Fraunhofer Institute for Mechanics of Materials IWM, Wohlerstr. 11, 79108 Freiburg, Germany 2 Karlsruhe Institute of Technology KIT, Institute for Applied Materials, Kaiserstr. 12,

A pharmacological modification of pain and epithelial

2015/4/15Results Mean UDVA at 1 month was LogMAR 0.028. The epithelial defect area was 10.91 mm 2 and 13.28 mm 2 at 24 hours and 1.39 mm 2 and 1.24 mm 2 at 48 hours for treated and nontreated eyes, respectively. Overall, 50% and 65% of treated and nontreated

Potential of Stimuli

Although the pre-formed gel and the in situ gel produced similar outcomes, the in situ gel provides consistent administration of therapeutic agents unlike pre-formed gel [20,31]. Moreover, the study has reported that Pluronic F-127 in situ gel causes significant stromal edema compared to MC and CMC pre-formed gel [ 32 ].

Tracking COL1A1 RNA in osteogenesis imperfecta. splice

This study illuminates the intra-nuclear fate of COL1A1 RNA in osteogenesis imperfecta (OI) Type I. Patient fibroblasts were shown to carry a heterozygous defect in splicing of intron 26, blocking mRNA export. Both the normal and mutant allele associated with a

In vivo study of polyurethane and tannin

2020/11/21The cause of human bone defect is mainly due to aging, tumor, trauma and other factors. 1 –3 Most bone defects cannot recover by themselves, bone transplantation is always needed. 2 –7 Traditional bone defect treatment or bone replacement includes autografts and allografts and the substitute tissues could rapidly osseointegrate with surrounding tissues after implantation. 7 However

Embryonic stem cell therapy improves bone quality in a

In the current study, we used an estrogen-deficient mouse model of osteoporosis to test the efficacy of a cell-generated bone tissue construct for bone augmentation of an impaired healing fracture. A reduction in new bone formation at the defect site was observed in ovariectomized fractures compared to the control group using repeated measures in vivo micro-computed tomography (μCT) imaging

Assessing the Impact of Defects on Lead‐Free

In this work, we established, for the first time, the wide applicability of PICTS for the in situ assessment of the defect parameters (i.e., energy depths, capture cross‐sections, and concentrations) of lead‐free PIMs, which have recently attracted a considerable

Noninvasive in vivo 3D bioprinting

Noninvasive installation of the conformal cell-laden scaffolds into the defect could avoid the implantation process–caused iatrogenic injury. Here, a conformal ASC-laden scaffold was noninvasively printed in situ for promoting the healing of the muscle defect in vivo.

Human Adipose Derived Stromal Cells Heal Critical Size

2010/6/17Background Human adipose-derived stromal cells (hASCs) represent a multipotent cell stromal cell type with proven capacity to differentiate along an osteogenic lineage. This suggests that they may be used to heal defects of the craniofacial or appendicular skeleton. We sought to substantiate the use of undifferentiated hASCs in the regeneration of a non-healing mouse skeletal defect

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